The article considers the problems of management in organizational systems of interaction between subjects of industrial entrepreneurship. Improving such systems expands the possibilities for intensifying and increasing the economic efficiency of industrial entrepreneurship. Entrepreneurial activity in key industries significantly influences the level and pace of development of the national economy and the country as a whole. During the study, methods of observation, system analysis, economic and mathematical modeling, hypothetico-deductive reasoning and generalization were used. As a result of the study, using the example of the petrochemical complex, various aspects of management modeling in organizational systems of interaction between business entities цуку described. A model for the formation and development of an organizational system of interaction between business entities in the petrochemical complex was developed. The structure and tools for managing interactions in such an organizational system were described. The factors determining the strength of relations between business entities in the petrochemical complex were identified. Specific indicators of the strength of relations between business entities in the industry were given. An approach was developed to assess the effectiveness of management in organizational systems of interaction between industry business entities. The use of the cause-and-effect relationships presented in the work should help accelerate the sustainable development of industry.